鶹madou

Dr Jaesung Choi

Dr Jaesung Choi

Lecturer

PhD, University of Sydney, 2016

BMedSci (Hons), University of Sydney, 2011

Medicine & Health
School of Biomedical Sciences

Dr Jaesung (Peter) Choi is a lecturer and group leader in the School of Biomedical Sciences at 鶹madou Sydney. A major focus of his research is to understand the molecular and metabolic mechanisms that drive endothelial cell malformation and its implications in vascular diseases (e.g. malformations, cancers), and identify novel therapies to the diseases. He has published numerous papers in high impact journals, including Nature, Science Advances, Journal of Experimental Medicine, Stroke and PLoS Biology. He is also a regular peer reviewer for NHMRC, MRFF, Heart Foundation and international journals.

Dr Choi completed his PhD in endocrine-related cancers at the ANZAC Research Institute and the University of Sydney in 2016. His PhD research was to understand the role of androgens via androgen receptors in endometrial, breast and prostate cancers. He was a postdoctoral research fellow in Vascular Biology program at the Centenary Institute (2016-9), and his research was to identify therapeutic targets and therapeutic options for a cardiovascular disease called cerebral cavernous malformation (CCM). In 2020, Dr Choi was awarded a highly prestigious UTS Chancellor’s Research Fellowship to lead the Cardiovascular and Stroke research program in the UTS Centenary Centre for Inflammation and appointed as a lecturer in the School of Life Sciences, UTS. Dr Choi then established his own research group at 鶹madou Sydney in early 2025.

For current projects, please contact Peter for more details.

Location
Room 322, Wallace Wurth 3East
  • Book Chapters | 2020
    Choi JP; Zheng X, 2020, 'Generation of cerebral cavernous malformation in neonatal mouse models using inducible Cre-loxP strategy', in Methods in Molecular Biology, pp. 253 - 258,
  • Journal articles | 2024
    Qian C; Zhou Y; Zhang T; Dong G; Song M; Tang Y; Wei Z; Yu S; Shen Q; Chen W; Choi JP; Yan J; Zhong C; Wan L; Li J; Wang A; Lu Y; Zhao Y, 2024, 'Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery', Acta Pharmaceutica Sinica B, 14, pp. 2077 - 2096,
    Journal articles | 2022
    Chopra N; Menounos S; Choi JP; Hansbro PM; Diwan AD; Das A, 2022, 'Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies', NEUROSCI, 3, pp. 1 - 27,
    Journal articles | 2021
    Choi JP; Yang X; He S; Song R; Xu ZR; Foley M; Wong JJL; Xu CR; Zheng X, 2021, 'CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway', Stroke, 52, pp. 1428 - 1436,
    Journal articles | 2021
    Wang R; Wu ST; Yang X; Qian Y; Choi JP; Gao R; Song S; Wang Y; Zhuang T; Wong JJL; Zhang Y; Han Z; Lu HA; Alexander SI; Liu R; Xia Y; Zheng X, 2021, 'Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting', JCI Insight, 6,
    Journal articles | 2020
    Donovan C; Liu G; Shen S; Marshall JE; Kim RY; Alemao CA; Budden KF; Choi JP; Kohonen-Corish M; El-Omar EM; Yang IA; Hansbro PM, 2020, 'The role of the microbiome and the NLRP3 inflammasome in the gut and lung', Journal of Leukocyte Biology, 108, pp. 925 - 935,
    Journal articles | 2020
    Hong CC; Tang AT; Detter MR; Choi JP; Wang R; Yang X; Guerrero AA; Wittig CF; Hobson N; Girard R; Lightle R; Moore T; Shenkar R; Polster SP; Goddard LM; Ren AA; Leu NA; Sterling S; Yang J; Li L; Chen M; Mericko-Ishizuka P; Dow LE; Watanabe H; Schwaninger M; Min W; Marchuk DA; Zheng X; Awad IA; Kahn ML, 2020, 'Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican', Journal of Experimental Medicine, 217,
    Journal articles | 2020
    Li J; Zhao Y; Choi J; Ting KK; Coleman P; Chen J; Cogger VC; Wan L; Shi Z; Moller T; Zheng X; Vadas MA; Gamble JR, 2020, 'Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice', PLoS Biology, 18,
    Journal articles | 2019
    Li J; Zhao Y; Coleman P; Chen J; Ting KK; Choi JP; Zheng X; Vadas MA; Gamble JR, 2019, 'Low fluid shear stress conditions contribute to activation of cerebral cavernous malformation signalling pathways', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865,
    Journal articles | 2018
    Choi JP; Wang R; Yang X; Wang X; Wang L; Ting KK; Foley M; Cogger V; Yang Z; Liu F; Han Z; Liu R; Baell J; Zheng X, 2018, 'Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations', Sci Adv, 4, pp. eaau0731,
    Journal articles | 2017
    Choi JP; Yang X; Foley M; Wang X; Zheng X, 2017, 'Induction and micro-CT imaging of cerebral cavernous malformations in mouse model', Journal of Visualized Experiments, 2017,
    Journal articles | 2017
    Tang AT; Choi JP; Kotzin JJ; Yang Y; Hong CC; Hobson N; Girard R; Zeineddine HA; Lightle R; Moore T; Cao Y; Shenkar R; Chen M; Mericko P; Yang J; Li L; Tanes C; Kobuley D; Võsa U; Whitehead KJ; Li DY; Franke L; Hart B; Schwaninger M; Henao-Mejia J; Morrison L; Kim H; Awad IA; Zheng X; Kahn ML, 2017, 'Endothelial TLR4 and the microbiome drive cerebral cavernous malformations', Nature, 545, pp. 305 - 310,
    Journal articles | 2016
    Choi JP; Foley M; Zhou Z; Wong WY; Gokoolparsadh N; Arthur JSC; Li DY; Zheng X, 2016, 'Micro-CT imaging reveals Mekk3 heterozygosity prevents cerebral cavernous malformations in Ccm2-deficient mice', PLoS ONE, 11,
    Journal articles | 2016
    Choi JP; Zheng Y; Handelsman DJ; Simanainen U, 2016, 'Glandular epithelial AR inactivation enhances PTEN deletion-induced uterine pathology', Endocrine-Related Cancer, 23, pp. 377 - 390,
    Journal articles | 2015
    Choi J; Desai R; Zheng Y; Yao M; Dong Q; Watson G; Handelsman DJ; Simanainen U, 2015, 'Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer', Endocrine-Related Cancer, 22, pp. 687 - 701,
    Journal articles | 2015
    Choi JP; Zheng Y; Skulte KA; Handelsman DJ; Simanainen U, 2015, 'Development and characterization of uterine glandular epithelium specific androgen receptor knockout mouse model', Biology of Reproduction, 93,
    Journal articles | 2014
    Choi J; Psarommatis B; Gao YR; Zheng Y; Handelsman DJ; Simanainen U, 2014, 'The role of androgens in experimental rodent mammary carcinogenesis', Breast Cancer Research, 16,
    Journal articles | 2014
    Zhao B; Choi J; Jaehne M; Gao YR; Desai R; Tuckermann J; Zhou H; Handelsman DJ; Simanainen U, 2014, 'Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate', Prostate, 74, pp. 1068 - 1078,

  1. Nature Science Foundation of China (NSFC) Project Grant 2023-6 (CIB) x2
  2. UTS Chancellor's Research Fellowship 2020-4 (CIA)
  3. NSW CVRN - Victor Chang Cardiac Research Institute Innovation Grant 2022 (CIA)
  4. Centenary Institute Early Career Booster Research Grant 2021 (CIA)
  5. NSW Health Investigator Development Grant 2020 (CIA)
  6. Seed Funding, Faculty of Science, UTS 2020 (CIA)
  7. Be Brave for Life Micro-Grant Award 2019 (CIA)
  8. Kenyon Family Foundation Inflammation Award 2018 (CIA)
  9. Be Brave for Life Micro-Grant Award 2018 (CIA)
  10. Brain foundation Research Gift Awards 2018 (CIB)
  11. Sydney Medical School Kick Start Grant 2017 (CIA)

  1. Centenary Institute International Travel Grant (2024, 2018, 2016)
  2. NSW CVRN Professional Development Award (2024, 2021)
  3. CASS Foundation Travel Award (2023, 2019)
  4. Australian Vascular Biology Society (AVBS) Achievement and Career Development Award (2022)
  5. AVBS Travel Award (2022, 2018)
  6. NAVBO-IVBM 2020 Poster Award (2020)
  7. 14th World Congress on Inflammation (WCI) Travel Award (2019)
  8. The FEBS Journal Poster Prize at Angioma Alliance’s CCM Scientific Meeting (2018)
  9. Sydney Medical School ECR overseas conference support grant (2017)
  10. ESA/IPSEN International Travel Grant Award (2015)
  11. Concord Repatriation General Hospital Research Travelling Scholarships (2014, 2013)
  12. University of Sydney, Postgraduate Research Support Scheme (2014, 2013, 2012)
  13. Endocrine Society of Australia (ESA) travel grant (2014, 2012)
  14. ICE/ENDO 2014 Travel grant (2014)
  15. EMBL Australia PhD Symposium Travel Grant (2013)
  16. Selected to attend inaugural EMBL Australia PhD course, Melbourne (2013)
  17. Sydney Medical School, Margaret Taylor Scholarship (2012)
  18. Postgraduate Cancer Research symposium, USYD, “Most outstanding presentation” (2012)

My Teaching

PHAR3111 - Clinical Pharmacology for Health and Exercise Science

PHAR3251 - Clinical and Experimental Pharmacology

PHAR3306 - Pharmacology for Optometry

MFAC2506 - Integrated Clinical Studies B