麻豆社madou
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Dr Muhammad Yasir

Dr Muhammad Yasir

Senior Research Associate

PhD in Medical Microbiology ( University of New South Wales, Sydney, Australia, 2020)

MPhil in Microbiology (Quaid-e-Azam University, Islamabad, Pakistan, 2013)

Medicine & Health
School of Optometry and Vision Science

My research focuses on investigating the mechanisms of action of newly designed antimicrobial peptides and peptidomimetics.听 These new antimicrobials are able to kill many different types of microbes including bacteria, fungi, and viruses. I am particularly interested in how these new antimicrobials prevent microbes from colonizing surfaces. My research has applications for preventing the transmission of disease and reducing the incidence of hospital-acquired infections.

E-mail
m.yasir@unsw.edu.au
  • Journal articles | 2024
    Bahatheg G; Kuppusamy R; Yasir M; Bridge S; Mishra SK; Cranfield CG; StC. Black D; Willcox M; Kumar N, 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, 147,
    Journal articles | 2024
    Hassan M; Shahzadi S; Yasir M; Chun W; Kloczkowski A, 2024, 'Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review', GENES, 15,
    Journal articles | 2024
    Hassan M; Yasir M; Shahzadi S; Chun W; Kloczkowski A, 2024, 'Molecular Role of Protein Phosphatases in Alzheimer's and Other Neurodegenerative Diseases', BIOMEDICINES, 12,
    Journal articles | 2024
    Hong Z; Yu TT; Yasir M; Sara M; Black DSC; Willcox MDP; Kuppusamy R; Kumar N, 2024, 'Daidzein-Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti-Biofilm Activity', ChemistrySelect, 9,
    Journal articles | 2024
    Kruse HV; Chakraborty S; Chen R; Kumar N; Yasir M; Lewin WT; Suchowerska N; Willcox MDP; McKenzie DR, 2024, 'Protecting Orthopaedic Implants from Infection: Antimicrobial Peptide Mel4 Is Non-Toxic to Bone Cells and Reduces Bacterial Colonisation When Bound to Plasma Ion-Implanted 3D-Printed PAEK Polymers', Cells, 13, pp. 656,
    Journal articles | 2024
    Sara M; Hui A; Yasir M; Peguda HK; Kalaiselvan P; Willcox M, 2024, 'Intrastromal Corneal Ring Implants Associated Bacterial Infections', Current Eye Research, 49, pp. 1012 - 1020,
    Journal articles | 2024
    Sara M; Yasir M; Kalaiselvan P; Hui A; Kuppusamy R; Kumar N; Chakraborty S; Yu TT; Wong EHH; Molchanova N; Jenssen H; Lin JS; Barron AE; Willcox M, 2024, 'The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens', Contact Lens and Anterior Eye, 47,
    Journal articles | 2024
    Yasir M; Park J; Chun W, 2024, 'Discovery of Novel Aldose Reductase Inhibitors via the Integration of Ligand-Based and Structure-Based Virtual Screening with Experimental Validation', ACS OMEGA, 9, pp. 20338 - 20349,
    Journal articles | 2024
    Yasir M; Park J; Han E-T; Han J-H; Park WS; Chun W, 2024, 'Identification of Malaria-Selective Proteasome 尾5 Inhibitors Through Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25,
    Journal articles | 2024
    Yasir M; Park J; Han E-T; Han J-H; Park WS; Chun W, 2024, 'Investigating the Inhibitory Potential of Flavonoids against Aldose Reductase: Insights from Molecular Docking, Dynamics Simulations, and gmx_MMPBSA Analysis', CURRENT ISSUES IN MOLECULAR BIOLOGY, 46, pp. 11503 - 11518,
    Journal articles | 2024
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Chun W, 2024, 'Drug Repositioning via Graph Neural Networks: Identifying Novel JAK2 Inhibitors from FDA-Approved Drugs through Molecular Docking and Biological Validation', MOLECULES, 29,
    Journal articles | 2024
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Chun W, 2024, 'Identification of Potential Tryptase Inhibitors from FDA-Approved Drugs Using Machine Learning, Molecular Docking, and Experimental Validation', ACS OMEGA, 9, pp. 38820 - 38831,
    Journal articles | 2024
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Chun W, 2024, 'Virtual Screening of Flavonoids against Plasmodium vivax Duffy Binding Protein Utilizing Molecular Docking and Molecular Dynamic Simulation', CURRENT COMPUTER-AIDED DRUG DESIGN, 20, pp. 616 - 627,
    Journal articles | 2024
    Yasir M; Willcox MDP, 2024, 'The use of ultraviolet light generated from light-emitting diodes for the disinfection of transvaginal ultrasound probes', PLoS ONE, 19, pp. e0298449,
    Journal articles | 2023
    Hassan M; Shahzadi S; Malik A; ud Din S; Yasir M; Chun W; Kloczkowski A, 2023, 'Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing's Sarcoma: A Composite Review', GENES, 14,
    Journal articles | 2023
    Hassan M; Shahzadi S; Yasir M; Chun W; Kloczkowski A, 2023, 'Computational prognostic evaluation of Alzheimer's drugs from FDA-approved database through structural conformational dynamics and drug repositioning approaches', SCIENTIFIC REPORTS, 13,
    Journal articles | 2023
    Kalaiselvan P; Yasir M; Vijay AK; Willcox MDP; Tummanapalli S, 2023, 'Longevity of hand sanitisers on fingers', Clinical and Experimental Optometry, 106, pp. 436 - 442,
    Journal articles | 2023
    Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585,
    Journal articles | 2023
    Mishra SK; Yasir M; Willcox M; Mishra Baishnab SK, 2023, 'Candida auris: an emerging antimicrobial-resistant organism with the highest level of concern', The Lancet Microbe, 4, pp. e482 - e483,
    Journal articles | 2023
    Willcox MDP; Bahatheg G; Carnt N; Kalaiselvan P; Kumar N; Kuppusamy R; Rayamajhee B; Sara M; Stapleton F; Vijay AK; Yasir M; Yu TT, 2023, 'Biofilms and contact lenses: problems and solutions', Microbiology Australia, 44, pp. 96 - 99,
    Journal articles | 2023
    Yasir M; Park J; Chun W, 2023, 'EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24,
    Journal articles | 2023
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Chun W, 2023, 'Computational Exploration of Licorice for Lead Compounds against Plasmodium vivax Duffy Binding Protein Utilizing Molecular Docking and Molecular Dynamic Simulation', MOLECULES, 28,
    Journal articles | 2023
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Chun W, 2023, 'Computational Exploration of the Effects of Mutations on GABA Aminotransferase in GABA Aminotransferase Deficiency', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24,
    Journal articles | 2023
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Chun W, 2023, 'Machine Learning-Based Drug Repositioning of Novel Janus Kinase 2 Inhibitors Utilizing Molecular Docking and Molecular Dynamic Simulation', JOURNAL OF CHEMICAL INFORMATION AND MODELING, 63, pp. 6487 - 6500,
    Journal articles | 2023
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Chun W, 2023, 'Vismodegib Identified as a Novel COX-2 Inhibitor via Deep-Learning-Based Drug Repositioning and Molecular Docking Analysis', ACS OMEGA, 8, pp. 34160 - 34170,
    Journal articles | 2023
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Hassan M; Kloczkowski A; Chun W, 2023, 'Exploration of Flavonoids as Lead Compounds against Ewing Sarcoma through Molecular Docking, Pharmacogenomics Analysis, and Molecular Dynamics Simulations', MOLECULES, 28,
    Journal articles | 2023
    Yasir M; Park J; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Hassan M; Kloczkowski A; Chun W, 2023, 'Investigation of Flavonoid Scaffolds as DAX1 Inhibitors against Ewing Sarcoma through Pharmacoinformatic and Dynamic Simulation Studies', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24,
    Journal articles | 2023
    Yasir M; Park J; Lee Y; Han E-T; Park WS; Han J-H; Kwon Y-S; Lee H-J; Chun W, 2023, 'Discovery of GABA Aminotransferase Inhibitors via Molecular Docking, Molecular Dynamic Simulation, and Biological Evaluation', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24,
    Journal articles | 2022
    Bahatheg G; Kuppusamy R; Yasir M; Black DSC; Willcox M; Kumar N, 2022, 'Short Tryptamine-Based Peptoids as Potential Therapeutics for Microbial Keratitis: Structure-Function Correlation Studies', Antibiotics, 11, pp. 1074,
    Journal articles | 2022
    Cometta S; Jones RT; Ju谩rez-Saldivar A; Donose BC; Yasir M; Bock N; Dargaville TR; Bertling K; Br眉nig M; Raki膰 AD; Willcox M; Hutmacher DW, 2022, 'Melimine-Modified 3D-Printed Polycaprolactone Scaffolds for the Prevention of Biofilm-Related Biomaterial Infections', ACS Nano, 16, pp. 16497 - 16512,
    Journal articles | 2022
    Hassan M; Yasir M; Shahzadi S; Kloczkowski A, 2022, 'Exploration of Potential Ewing Sarcoma Drugs from FDA-Approved Pharmaceuticals through Computational Drug Repositioning, Pharmacogenomics, Molecular Docking, and MD Simulation Studies', ACS OMEGA, 7, pp. 19243 - 19260,
    Journal articles | 2022
    Kalaiselvan P; Yasir M; Kuppusamy R; Willcox M; Vijay AK, 2022, 'Ability of Essential Oil Vapours to Reduce Numbers of Culturable Aerosolised Coronavirus, Bacteria and Fungi', Antibiotics, 11, pp. 393,
    Journal articles | 2022
    Khan HA; Yasir M; Castel A, 2022, 'Performance of cementitious and alkali-activated mortars exposed to laboratory simulated microbially induced corrosion test', Cement and Concrete Composites, 128,
    Journal articles | 2022
    Khosravanihaghighi A; Koshy P; Yasir M; Romanazzo S; Lovric V; Kilian KA; Willcox MD; Walsh WR; Sorrell CC, 2022, 'Production of Antibacterial Activity and Bone Cell Proliferation by Surface Engineering of Ga- or Mn-Doped Ceria-Coated Biomedical Titanium Alloy', Advanced Engineering Materials, 24,
    Journal articles | 2022
    Magar LB; Rayamajhee B; Khadka S; Karki G; Thapa A; Yasir M; Thapa S; Panta OP; Sharma S; Poudel P, 2022, 'Detection of Bacillus Species with Arsenic Resistance and Plant Growth Promoting Efficacy from Agricultural Soils of Nepal', Scientifica, 2022,
    Journal articles | 2022
    Yasir M; Kumar Vijay A; Willcox M; Vijay A, 2022, 'Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus', Contact Lens and Anterior Eye, 45, pp. 101513,
    Journal articles | 2022
    Yasir M; Nawaz A; Ghazanfar S; Okla MK; Chaudhary A; Al WH; Ajmal MN; AbdElgawad H; Ahmad Z; Abbas F; Wadood A; Manzoor Z; Akhtar N; Din M; Hameed Y; Imran M, 2022, 'Anti-bacterial activity of essential oils against multidrug-resistant foodborne pathogens isolated from raw milk.', Braz J Biol, 84, pp. e259449,
    Journal articles | 2021
    Bhattacharjee S; Joshi R; Chughtai A; Heslop D; Wilcox M; MacIntyre R, 2021, 'Graphene and nanoparticles coated antimicrobial and biocompatible cotton/silk fabrics for protective clothing', ACS Applied Bio Materials
    Journal articles | 2021
    Din M; Babar KM; Shah D; Sarwar G; Khan S; Sadaf H; Ahmed SS; Ali FL; Yasir M; Ahmed N, 2021, 'Dissemination of NDM-1 in pseudomonas aeruginosa and klebsiella pneumoniae isolated from pus samples in tertiary care hospitals of Quetta, Pakistan', Journal of the Pakistan Medical Association, 71, pp. 228 - 232,
    Journal articles | 2021
    Yasir M; Dutta D; Willcox MDP, 2021, 'Enhancement of Antibiofilm Activity of Ciprofloxacin against Staphylococcus aureus by Administration of Antimicrobial Peptides', Antibiotics, 10, pp. 1 - 17,
    Journal articles | 2021
    Yasir M; Dutta D; Willcox MDP, 2021, 'Enhancement of antibiofilm activity of ciprofloxacin against staphylococcus aureus by administration of antimicrobial peptides', Antibiotics, 10, pp. 1159,
    Journal articles | 2021
    Yu TT; Kuppusamy R; Yasir M; Hassan MM; Sara M; Ho J; Willcox MDP; Black DS; Kumar N, 2021, 'Polyphenylglyoxamide鈥恇ased amphiphilic small molecular peptidomimetics as antibacterial agents with anti鈥恇iofilm activity', International Journal of Molecular Sciences, 22, pp. 7344,
    Journal articles | 2020
    Cho K; Yasir M; Jung M; Willcox MDP; Stenzel MH; Rajan G; Farrar P; Prusty BG, 2020, 'Hybrid engineered dental composites by multiscale reinforcements with chitosan-integrated halloysite nanotubes and S-glass fibers', Composites Part B: Engineering, 202,
    Journal articles | 2020
    Willcox MDP; Chen R; Kalaiselvan P; Yasir M; Rasul R; Kumar N; Dutta D, 2020, 'The development of an antimicrobial contact lens 鈥 from the laboratory to the clinic', Current Protein and Peptide Science, 21, pp. 357 - 368,
    Journal articles | 2020
    Yasir M; Dutta D; Hossain KR; Chen R; Ho KKK; Kuppusamy R; Clarke RJ; Kumar N; Willcox MDP, 2020, 'Mechanism of Action of Surface Immobilized Antimicrobial Peptides Against Pseudomonas aeruginosa', Frontiers in Microbiology, 10, pp. 3053,
    Journal articles | 2020
    Yasir M; Dutta D; Kumar N; Willcox MDP, 2020, 'Interaction of the surface bound antimicrobial peptides melimine听and Mel4 with Staphylococcus aureus', Biofouling, 36, pp. 1019 - 1030,
    Journal articles | 2020
    Yasir M; Dutta D; Willcox MDP, 2020, 'Activity of Antimicrobial Peptides and Ciprofloxacin against Pseudomonas aeruginosa Biofilms', Molecules, 25, pp. 3843,
    Journal articles | 2020
    Yu TT; Kuppusamy R; Yasir M; Hassan MM; Alghalayini A; Gadde S; Deplazes E; Cranfield C; Willcox MDP; Black DS; Kumar N, 2020, 'Design, synthesis and biological evaluation of biphenylglyoxamide-based small molecular antimicrobial peptide mimics as antibacterial agents', International Journal of Molecular Sciences, 21, pp. 1 - 38,
    Journal articles | 2019
    Tran C; Yasir M; Dutta D; Eswaramoorthy N; Suchowerska N; Willcox M; McKenzie DR, 2019, 'Single Step Plasma Process for Covalent Binding of Antimicrobial Peptides on Catheters to Suppress Bacterial Adhesion', ACS Applied Bio Materials, 2, pp. 5739 - 5748,
    Journal articles | 2019
    Yasir M; Dutta D; Willcox MDP, 2019, 'Author Correction: Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa (Scientific Reports, (2019), 9, 1, (7063), 10.1038/s41598-019-42440-2)', Scientific Reports, 9, pp. 13267,
    Journal articles | 2019
    Yasir M; Dutta D; Willcox MDP, 2019, 'Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa', Scientific Reports, 9, pp. 7063,
    Journal articles | 2019
    Yasir M; Dutta D; Willcox MDP, 2019, 'Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability', PLoS ONE, 14, pp. e0215703,
    Journal articles | 2018
    Kuppusamy R; Yasir M; Berry T; Cranfield CG; Nizalapur S; Yee E; Kimyon O; Taunk A; Ho KKK; Cornell B; Manefield M; Willcox M; Black DSC; Kumar N, 2018, 'Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents', European Journal of Medicinal Chemistry, 143, pp. 1702 - 1722,
    Journal articles | 2018
    Kuppusamy R; Yasir M; Yee E; Willcox M; Black DSC; Kumar N, 2018, 'Guanidine functionalized anthranilamides as effective antibacterials with biofilm disruption activity', Organic and Biomolecular Chemistry, 16, pp. 5871 - 5888,
    Journal articles | 2018
    Yasir M; Willcox MDP; Dutta D, 2018, 'Action of antimicrobial peptides against bacterial biofilms', Materials, 11, pp. 2468,
  • Conference Papers | 2022
    Sara M; Alex H; Chen R; Kumar N; Rajesh K; Kumar Mishara SK; Barron A; Yasir MUHAMMAD; Willcox M; Yasir M, 2022, 'Antimicrobial activity of peptoids against clinical pathogens.', in Antimicrobial activity of peptoids against clinical pathogens., USA, presented at peptoidsummit2022, USA, 11 August 2022 - 12 August 2022
    Conference Presentations | 2021
    Bhattacharjee S; Joshi R; Yasir M; Adhikari A; Chughtai A; Heslop D; Bull R; Willcox M; MacIntyre R, 2021, 'Next-generation PPE: synergistic antimicrobial activity and low-cytotoxicity of graphene-derivative and nanoparticles on cotton/silk fabrics', presented at MRS Fall Meeting & Exhibit 2021, 06 December 2021 - 08 December 2021
    Preprints | 2021
    Kalaiselvan P; Yasir M; Willcox M; Vijay AK, 2021, Efficacy of anti-microbial gel vapours against aerosolised coronavirus, bacteria, and fungi,
    Conference Abstracts | 2021
    Sara M; Kuppusamy R; Afzal M; Khan M; Yasir M; Kalaiselvan P; Hui A; Kumar N; Willcox M, 2021, 'Synergistic activity of a peptide mimic with quinolones and cephalosporins against Staphylococcus aureus', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vol. 62,
    Conference Papers | 2018
    Mohammad Y; Dutta D; Willcox MARKDUNCAN, 2018, 'The role of antimicrobial peptides in reducing bacterial biofilms', Sydney, presented at Molecular Microbiology Meeting, Sydney, 11 April 2018 - 12 April 2018
    Preprints | 2018
    Yasir M; Dutta D; Willcox MDP, 2018, Comparative mode of action of antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa,

Contract Research Grant (AUS$ 300,000)听

  • 听 听 听Bridge and BridgeTech REDI Fellowship through MTP connects ($10000)
  • 听 听 听Academic Research Excellence Research Award by School of Optometry and Vision Science 麻豆社madou
  • 听 听 听 Travel award from Association for Research in Vision and Ophthalmology (ARVO) virtual meeting (USA) ($2500)
  • 听 听 听Best paper award from the school of Optom and Vision Science 麻豆社madou Sydney Australia ($1000)
  • 听 听 听Science writing fellowship award from Faculty of Science, University of New South Wales Australia ($6000)
  • 听 听 听Travel ward from International Society for Contact Lens Research (ISCLR meeting in (Singapore) ($5000)
  • 听 听 听Travel Award from American Society for Microbiology (ASM meeting in Sans Francisco) ($2000)
  • 听 听 听Travel award for World Life Science Conference Beijing, China ($3000)
  • 听 听 听Cornea and Contact Lens Society of Australia (CCLSA) research award ($3500)
  • 听 听 听Best abstract award in Molecular Microbiology Meeting by Australian Society for Microbiology ($500)
  • 听 听 听Top Up Scholarship from School of Optometry and Vision Science 麻豆社madou ($28000)
  • 听 听 听Teaching Fellowship award from School of Optometry and Vision Science 麻豆社madou.
  • 听 听 听Ph.D Scholarship from University of New South Wales.
  • 听 听 听Higher Education awards for FATA and Balochistan students by HEC Pakistan (0.25 milliom PKR).
  • 听 听 听First class 1st position in M.Sc (Gold Medal) with 0.1 million PKR cash prize.
  • 听 听 Talent Farming Scholarship for M.Sc by Higher Education Commission (HEC) Pakistan 听(0.1 million PKR)

  • Activity and mechanism of action of antimicrobial peptides (natural and synthetic)
  • Mechanism of action of surface-bound antimicrobial peptides and peptidomimetics听
  • Antimicrobial activity and mode of action of natural products (plants based)
  • Anti-viral, anti-bacterial, and anti-fungal activity of disinfectants and biomedical devices听
  • Synergistic activity of multipurpose disinfecting solution and peptides mimics
  • Development of drug resistance in planktonic and colonized bacteria
  • Biofilms and their control strategies

Professional membership:

American Society for Microbiology

Australian Society for Microbiology听

Cornea and Contact Lens Society of Australia听

My Research Supervision

Manjulatha Sara -PhD Co-supervisor

听

Shakeel Shahzad -PhD Co-supervisor听听

听

Jiawei Shen -PhD Co-supervisor